The Buffalo Bills have barely had time to enjoy their explosive victory over the Detroit Lions, but attention in Western New York is already beginning to shift toward the next challenge.
And this one brings another dangerous AFC opponent to Buffalo.
The Buffalo Bills will host the Los Angeles Chargers on Sunday, September 27, 2026, with kickoff scheduled for 1:00 p.m. ET at Highmark Stadium in Orchard Park, New York. The game will be nationally distributed through FOX’s Sunday afternoon NFL coverage, according to the Bills’ official 2026 schedule and the NFL schedule.
For Bills Mafia, that means there is no complicated primetime schedule to remember this week:
Sunday. 1:00 p.m. ET. FOX.
And after Buffalo’s spectacular start to the season, there should be plenty of attention surrounding this matchup.
🔥 Buffalo Enters Week 3 With Momentum
The Bills couldn’t have asked for a much more exciting beginning to the Joe Brady era.
Buffalo opened its season by defeating the Houston Texans 36–31 on the road. Four days later, the Bills returned home and produced another offensive explosion, beating the Detroit Lions 41–31 in the first regular-season game at the new Highmark Stadium.
That moved Buffalo to 2–0.
But the biggest story from the Detroit victory was once again Josh Allen.
The Bills quarterback accounted for an incredible five total touchdowns, throwing three and rushing for two as Buffalo’s offense repeatedly found ways to punish Detroit.
Allen completed 20 of 31 passes for 248 yards and added 69 yards on the ground.
It was exactly the type of performance that reminds the rest of the NFL what Buffalo’s offense can become when Allen is controlling the game with both his arm and his legs.
Now comes another test.
Josh Allen vs. Justin Herbert Brings Star Power
If both quarterbacks are healthy and available, one of the biggest attractions surrounding Bills-Chargers will be the quarterback matchup.
Josh Allen vs. Justin Herbert.
Two powerful arms.
Two quarterbacks capable of changing a game almost instantly.
And two AFC franchises with significant expectations surrounding them.
Herbert and the Chargers still have business to handle before traveling east. Los Angeles hosts the Las Vegas Raiders on September 20, meaning its Week 2 result will shape the storyline entering Buffalo. As of September 19, the Chargers were 0–1 following their season-opening loss to Arizona.
That creates an important difference between the teams’ schedules.
Buffalo played Detroit on Thursday night, giving the Bills additional recovery time before Week 3.
Los Angeles plays Sunday before traveling across the country to Buffalo.
Those extra days could become valuable for Joe Brady’s team, particularly with several injury situations worth monitoring.
🚨 Buffalo’s Injury Situation Will Matter
One name Bills fans will be watching closely is DJ Moore.
The wide receiver left Buffalo’s victory over Detroit with a shoulder injury, and his status for Week 3 remained uncertain immediately afterward. NFL coverage following the Lions game identified Moore’s availability against Los Angeles as a question heading into the extended break.
That is precisely why Buffalo’s unusual early-season schedule could help.
The Bills played Houston on Sunday and Detroit four days later on Thursday. They now don’t play again until September 27.
That gives Buffalo more than a full week to recover and prepare.
For Brady and his coaching staff, those days provide an opportunity to evaluate injured players while beginning preparations for Jim Harbaugh’s Chargers.
How Can Fans Watch Bills vs. Chargers?
The television situation is simple.
FOX is the listed broadcaster for the September 27 matchup. Buffalo’s official schedule confirms the 1:00 p.m. ET kickoff and FOX assignment.
For viewers in an area carrying the game, FOX says local NFL games can be streamed through its authenticated digital options with participating TV-provider credentials. Out-of-market Sunday afternoon availability can differ; the Bills’ viewing guide also points fans to NFL Sunday Ticket through YouTube/YouTube TV for eligible out-of-market games, subject to applicable restrictions.
Radio listeners in the Buffalo market can also follow Bills broadcasts through 97 Rock WGRF-FM, the team’s flagship station beginning with the 2026 season.
📺 Full Bills vs. Chargers Viewing Information
Matchup: Los Angeles Chargers at Buffalo Bills
Date: Sunday, September 27, 2026
Kickoff: 1:00 p.m. ET
TV: FOX
Stadium: Highmark Stadium, Orchard Park, New York
Buffalo radio flagship: 97 Rock WGRF-FM
Buffalo Has a Chance to Keep Building
There is another reason this game matters.
Buffalo’s opening stretch has created an opportunity to establish momentum before the schedule becomes increasingly complicated.
After Los Angeles, the Bills remain home to face the New England Patriots on October 4. Then they travel west for a Monday Night Football matchup against the Los Angeles Rams on October 12.
But looking beyond the Chargers would be dangerous.
Los Angeles has a talented quarterback, an experienced head coach in Jim Harbaugh and enough talent to make Buffalo pay for mistakes.
For the Bills, the objective will be straightforward: keep the offense aggressive, protect Allen, continue establishing the running game and use the extended preparation window to get as healthy as possible.
Buffalo has already survived two high-scoring games.
The Bills have already scored 77 points through two weeks.
And Allen has already produced one of the most memorable performances of the young season in Buffalo’s new stadium.
Now Bills Mafia gets another Sunday at home.
Chargers vs. Bills. September 27. 1:00 p.m. ET. FOX.
After a 2–0 start, Buffalo’s next opportunity to keep the momentum rolling is officially on the horizon.
